NA-mech
A web application providing sequence-dependent structure and mechanical deformability of DNA and RNA double helices at the rigid base level, including a non-local stiffness matrix, as well as sequence-dependent width and stiffness of the minor and major grooves. It is based on our all-atom, explicit-solvent molecular dynamics simulations of DNA and RNA duplexes involving all hexanucleotide sequeces. Please cite us: Slavníková et al., J. Chem. Inf. Model. 2025, https://doi.org/10.1021/acs.jcim.5c00576